![]() This study examines the relation between seizure and plasma tramadol concentration in patients with tramadol poisoning, as a novel centrally acting analgesic used for the treatment of mild to severe pain. The only serious injury associated with this type of seizure was the head injury, present in approximately 1% of the patients. No statistically significant difference was found between patients with and without trauma associated with tramadol-induced seizures in terms of age, gender, ingested dose by history, positive history of addiction to other opioids, and number of episodes of seizure. The prevalence of trauma was 24.6% (in 57 patients) with the most frequent site of trauma to the face (9.5%) followed by shoulder (4.3%), head (3%), trunk (1.7%), and upper extremities (1.3%). Seizure episodes had occurred once in 207 (89.2%), twice in 21 (9.1%), and three times in 4 (1.7%) patients. History of tramadol abuse was positive in 114 (49.1%) patients. The mean dose ingested by the history was 1416 +/- 1124 mg. Of them, 185 (79.7%) had referred within the first 6 hours after ingestion. The patients' data including age, gender, ingested dose by history, route of exposure, manner of poisoning, previous history of suicidal attempts, previous history of drug or substance abuse, history of tramadol abuse, type of the seizure, number of episodes of seizure before presentation or after admission, site of the trauma, and type of injury were recorded.Ī total of 232 patients were included in the study. To determine the prevalence, type and site of the injuries due to tramadol-induced seizures in the patients who had referred after its overdose or use of its therapeutic dose.Īll patients referring to Loghman Hakim Poison Hospital (February 2009 to April 2010) due to tramadol-induced seizures were included. Although data reflect 20 years of clinical experience with tramadol, intraoperative experience remains limited due to historical concerns of accidential awareness with an outdated anaesthetic technique that has been superseded. Tramadol also lacks the prostaglandin inhibition-mediated adverse effects of the nonsteroidal anti-inflammatory drugs. ![]() Tramadol causes minimal dependence and tolerance and has very low abuse potential consequently it is not scheduled as a controlled drug. Tramadol is demonstrably inferior to morphine in severe pain however, it is free of some of the clinically significant adverse effects seen with other opioid analgesics of similar efficacy, particularly respiratory depression. The two enantiomers of tramadol, and its principle metabolite O- desmethyltramadol, produce relief of moderate to severe pain across the range of acute and chronic pain states by combining synergistically weak opioid and monoaminergically-mediated antinociceptive mechanisms. ![]() The attributes of tramadol hydrochloride provide the clinician with a useful analgesic for short- and longterm use in the hospital and community settings. Cause of death in this patient can be seen as the side effects of tramadol poisoning. Despite medical managements, he died 38 days after ingestion.Ĭonclusion: In this report, despite using inhalational anesthetic drugs, seizures continued and were very poorly controlled. At admission, he experienced hypovolemic shock, hypoglycemia, coma, apnea, refractory seizures, muscle spasms, acute respiratory distress syndrome, coagolative disorder, rhabdomyolysis, and acute renal failure. Due to respiratory arrest, endotracheal tube was inserted and he was admitted to the ICU immediately. Generalized seizures were poorly controlled by multiple medications. ![]() He presented with generalized seizures two hours post ingestion, and, then, he was referred to hospital four hours later. There was no history of epilepsy or head trauma in. He had history of suicidal attempts in past years as well as depression in his past medical history, but he had not abused tramadol and other drugs in his history. Tramadol poisoning can induce CNS depression, seizures, coma, and ultimately death.Ĭase: In this report, a 30-year-old male was admitted to the emergency department due to suicidal attempt with ingestion of 14000 mg (140 tablet 100 mg) of tramadol. Background: Tramadol, an analgesic drug abused by opioid addicts, is also abused accidentally or for suicidal purposes. ![]()
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